A new study analyzing data from more than 60 previous research projects has found evidence that there is "no safe amount" of processed meat consumption -- so much so that even small daily portions are being linked to increased disease risk. The research, published Monday in the journal Nature Medicine, examined connections between processed meats, sugar-sweetened beverages and trans fatty acids and the risk of type 2 diabetes, colorectal cancer and ischemic heart disease. People who ate as little as one hot dog daily showed an 11% greater risk of type 2 diabetes and 7% increased risk of colorectal cancer compared to those who consumed none. Drinking approximately one 12-ounce soda per day was associated with an 8% increase in type 2 diabetes risk and 2% increased risk of ischemic heart disease.

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Moderna's mRNA-based seasonal flu vaccine proved 27% more effective at preventing influenza infections than standard flu shots in a Phase 3 trial involving nearly 41,000 people aged 50 and above, the firm said this week. The company announced that mRNA-1010 had an overall vaccine efficacy that was 26.6% higher than conventional shots, rising to 27.4% higher in participants aged 65 and older during the six-month study period. The 2024-2025 flu season hospitalized an estimated 770,000 Americans, according to the Centers for Disease Control and Prevention.

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To grow Expert Generalists we need to focus attention on fundamentals rather tools. As an example, Unmesh, Gitanjali, and I describe a workshop we've used to break silos of application development, data engineering, and devops

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We have two crucial checkpoints for spotting — and then nurturing — expert generalists. Unmesh, Gitanjali, and I look at hiring and career progression.

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One key reason why the Commodore 64 was so successful in the 80s was that it was able to do things it wasn’t designed for. Freezer cartridges, which allowed stopping any running program or game, applying cheat codes and resuming, or saving the complete computer’s state to disk so it could be continued from later, were one of those clever innovations: They were possible on the Commodore 64, but not on many other computers.

A Commodore 64 with a good cartridge was a significantly more capable computer than a Commodore 64 without, this did contribute to the longevity of the computer and is one reason why the Commodore 64 could remain in production for more than a decade.

However, because the Commodore 64 wasn’t designed at all to support freezing, a cartridge has to exploit quirks in the hardware in order to achieve its functionality. The C64 feature that is essential to freezer cartridges is the so-called Ultimax mode.

Check out Michael Steil’s article on pagetable.com with additional details.

And see GitHub for reverse engineering one cartridge.

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